Image of a Man
Selecting the
right dose for
your patient.

DOSING PARAMETERS &
TREATMENT INITIATION

Getting started with CUVITRU

When you start a patient on CUVITRU their dose is determined by whether they are switching from an IVIG treatment, HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] Solution, or other SCIG treatments.

Patients who are:

Switching from IVIG
treatment or HYQVIA
1

Treatment with CUVITRU should begin 1 week after the patient’s last IVIG or HYQVIA infusion.

Establish the initial weekly dose by converting the monthly IVIG or HYQVIA dose into an equivalent weekly dose and increasing it using a dose adjustment factor (1.30).

Initial weekly dose = Previous IVIG or HYQVIA dose (in grams) / Number of weeks between IVIG or HYQVIA doses * 1.30

Switching from SCIG
treatment
1

The initial weekly dose is recommended to be the same as the weekly dose of the prior SCIG treatment.

÷

Regardless of prior IG treatment history, if the desire is to dose CUVITRU more frequently than once weekly, divide the calculated weekly dose by the desired frequency per week1

×2

If the desired frequency is biweekly, multiply the weekly dose1 by 2

×5

Multiply the calculated dose by 5 to convert from grams to milliliters1

Initial and subsequent infusion rate parameters

The rate of infusion and volume per site should be adjusted based on each individual
patient's needs, preferences, and ability to tolerate treatment.

Infusion Volume and Rate*1
Infusion
Paramaters
First Two Infusions Subsequent Infusions
Patients <40kg Patients ≥40kg Patients <40kg Patients ≥40kg
Volume (mL/site) ≤20 ≤60 ≤60
Rate (mL/h/site) 10-20 ≤60

*If the initial infusions are well tolerated, then subsequent infusions can be administered at the maximum tolerated rate.

Personalizing dose adjustments

Individualize each patient's dose by monitory pharmacokinetic and clinical response, as well as IgG trough levels, making dose adjustments as needed.1

Change in Volume to Be Administered Weekly/Biweekly for Intended IgG Trough Level Changea1

Body Weight
Difference
from Target
Serum IgG
Trough
Levels
Dosing
Frequency
30 kg 50 kg 70kg 90 kg 110 kg
100 mg/dL Weekly 3 mL 5 mL 7 mL 9 mL 11 mL
Biweekly 6 mL 10 mL 13 mL 17 mL 21 mL
200 mg/dL Weekly 6 mL 10 mL 13 mL 17 mL 21 mL
Biweekly 12 mL 19 mL 27 mL 35 mL 42 mL
300 mg/dL Weekly 9 mL 14 mL 20 mL 26 mL 32 mL
Biweekly 17 mL 29 mL 40 mL 52 mL 63 mL

aDerived using a linear approximation of trough levels and weekly dose per kg body mass with a slope of 52.1 kg/dL.
If the difference between measured and target trough levels is <100 mg/dL, then no adjustment is necessary.1

Explore administration parameter combinations based on needlesticks and infusion frequency, and check out the proper ancillary supplies.

Infusion Calculator & Ancillary Supplies
  1. CUVITRU [Prescribing Information]. Lexington, MA: Baxalta US Inc.
  2. Suez D, Stein M, Gupta S, et al. Efficacy, safety, and pharmacokinetics of a novel human immune globulin subcutaneous, 20% in patients with
    primary immunodeficiency diseases in North America. J Clin Immunol. 2016;36(7):700-712.